Milbemycin oxime CAS NO.129496-10-2

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Milbemycin oxime Chemical Properties Melting point 169.6-177.4° Fp 412℃ InChIKey LKMMLHTWKLEARD-MGZQXKBQSA-N Safety Information RIDADR 2588 HazardClass 6.1(b) PackingGroup III MSDS Information Milbemycin oxime Usage And Synthesis Uses Milbemycin oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of a mixture of two natural products, milbemycin A3 and A4 (in ~30:70 ratio). Milbemycin oxime is used therapeutically for the prevention of intestinal parasites in dogs. Like the other milbemycin/avermectins, it was developed for intestinal parasite control in animals and acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking. Uses controls intestinal parasites in animals Uses Milbemycin oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of an 80:20 ratio of milbemycin A3 and A4 . Like other milbemycin/avermectins, it can potentiate glutamate and GABA-gated chloride-channel opening and is used as a nematocide and insecticide in veterinary medicine.