Keywords

• AF-802;CH-5424802/RG-7853;Alectinib (CH5424802);Alectinib;AF-802,RG-7853
• 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Alectinib (CH5424802);CH5424802-alectinib;
• 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile CH5424802

Quick Details

• ProName: 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4...
• CasNo: 1256580-46-7
• Molecular Formula: C30H34N4O2
• Application: CH5424802 is a highly selective and po...
• PackAge: according to client's requirments
• Port: Shanghai,Tianjin, Qingdao
• ProductionCapacity: Metric Ton/Day
• Purity: 99%
• Storage: White to Off-White Solid
• Transportation: BY AIR, BY SEA
• LimitNum: 1 Metric Ton

Superiority

9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Chemical Properties density 1.28 Safety Information MSDS Information 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Usage And Synthesis Bioactivity Alectinib (CH5424802) is an efficient ALK inhibitor. Its IC50 is 1.9nM and it is sensitive to the L1196M mutant, which is highly selective for ALK than PF-02341066, NVP-TAE684 and PHA-E429. Solubility In vitro (25 ° C): DMSO-2 mg/mL heating (4.14 mM); Water-<1 mg/mL (<1 mM); Ethanol-<1 mg/mL (<1 mM) In vivo (25 ° C): 30% PEG 400/0.5% Tween 80/5% propylene glycol-30 mg/mL.

Details

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