Keywords

• 5-chloro-2-N-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl]-4-N-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine;(2-((5-Chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)py
• AP26113/AP-26113;5-chloro-N2-(4-(4-(diMethylaMino)piperidin-1-yl)-2-Methoxy-5-Methylphenyl)-N4-(2-(diMethylphosphoryl)phenyl)pyriMidine-2,4-diaMine;5-Chloro-N2-[4-[4-(dimethylamino)-1-piperidinyl]-2-m
• 5-Chloro-N2-[4-[4-(diMethylaMino)-1-piperidinyl]-2-Methoxyphenyl]-N4-[2-(diMethylphosphinyl)phenyl];2,4-Pyrimidinediamine, 5-chloro-N2-[4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl]-N4-[2-(dime

Quick Details

• ProName: AP26113
• CasNo: 1197958-12-5
• Molecular Formula: C27H36ClN6O4P
• Application: pharmaceutical intermediate
• PackAge: according to client's requirments
• Port: Shanghai,Tianjin, Qingdao
• ProductionCapacity: Metric Ton/Day
• Purity: 99%
• Transportation: BY AIR, BY SEA
• LimitNum: 1 Metric Ton

Superiority

Searchingredient.com concentrates on building a global leading search engine for ingredients in food, feed and pharmaceutical industry, thanks to its strong backgrounds in food, beverage and pharmaceutical raw material business. Buyers may get precise quotations for almost any food and feed ingredients, active pharmaceutical ingredients and relevant chemical reagents within 24 hours online at zero cost, as searchingredient.com has developed close ties with more than 100,000 certified suppliers worldwide over the past years, and a reliable inquiry tracking team and system. Searchingredient.com product database covers more than 20,000 food ingredients, active pharmaceutical ingredients and relevant chemical reagents, forming a professional reference book and dictionary of the industry, its high-standard chemical information data ranging from CAS No., EC No., molecular formula, molecular weight, product description, product synonyms to molecular structure. In the meantime, searchingredient.com owns a professional editorial team with international perspective, which focuses on collection of all sorts of industry information and provides industry news, market development tracking, in-depth analysis report and business review for suppliers, manufacturers, traders and purchasing agents from the food, feed and active pharmaceutical ingredients industry worldwide.

Details

Description AP26113 (also known as Brigatinib) is an investigated small molecule for targeted cancer therapy. It is a potent dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It is mainly under investigation for its treatmentefficacy on non-small cell lung cancer (NSCLC) where ALK is activated and EGFP mutations frequently occur. Biological activity AP26113 is a kind of effective ALK inhibitor with an IC50 of 0.62 nM, being able to overcome the L1196M mutation-mediated Crizotinib resistance; Phase 2.